Anabolik androjenik steroid

The aim of this study is to asses the impact of subacute and subchronic administration testosterone and dehydroepiandrosterone on echocardiographic, pathologic and oxydative stress parameters in Sprague-Dawley rats. In our study, we compared the impact of subacute and subchronic administration testosterone and dehydroepiandrosterone on echocardiographic and morphological parameters in heart and oxydative stress markers with the control group. In this study, we have approached the conclusion that subacute and subchronic testosterone and DHEA administration decreased the body weights and locomotor activity (p<0,05), and they increased muscle strength (p<0,05) in rats. According to our pathological assesment, mishappen cell nuclei, interstitial fibrosis, disorganized myocardial fibers and leukocytic infiltrates were observed in high dose testosterone (100mg/ 100gr) –treated rats especially on 14th day. In subchronic (90 days) testosterone and DHEA treatment groups, mild changes such as mishappen cell nuclei, interstitial fibrosis, disorganized myocardial fibers and leukocytic infiltrates were observed. According to our echocardiographic study at 14th and 90th days, testosterone, especially at high doses, induced increase in left ventricular posterior wall diameter and ejection fraction (p<). In this study, oxidative stress marker MDA increased slighty but significantly in testosterone and DHEA the other hand, SOD and GSHPx levels were slighty but not significantly increased intestosterone and DHEA groups. In conclusion, long term and high dose AAS administration has been found to create possible deleterious effects on heart and should be strongly discouraged in human subjects.

Anabolik androjenik steroid

anabolik androjenik steroid

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