Cardiovascular strain is one of the more pronounced and serious Anadrol side effects. Cardiovascular strain and negative cholesterol changes are a side effect common among all anabolic steroids, and especially oral steroids . This involves the reduction of HDL (the good cholesterol) and increases of LDL (the bad cholesterol). The result of such changes involves an increased risk of arteriosclerosis, and the degree to which these changes occur for the worse are usually dose-dependent (with higher doses increasing the negative changes and the risks). Other factors that affect these negative cholesterol changes are: duration of use, and route of administration. In terms of the route of administration, oral anabolic steroids are known for having a reputation as being much worse for their negative impacts on cholesterol in comparison to injectable anabolic steroids . This is because the liver serves to function as the cholesterol processing center for the human body, and the increased hepatotoxicity associated with anabolic steroids will result in even worse negative cholesterol changes. Anadrol in particular is extremely notorious for this, as its resistance to structural breakdown in the liver is very high. Studies whereby a group of males administered 50 – 100mg of Anadrol for a 12 week period have demonstrated dangerously significant increases in LDL and reduction of HDL (reduced by 19 – 23 points)  .