Long before the era of high-throughput screening and genomics, drug discovery relied heavily on natural compounds. In fact, many of the drugs available today contain active ingredients extracted from natural products. Since 1994, nearly half of all drugs were discovered using natural products. Furthermore, between 2005 and 2007, there were 13 new drugs based on natural products that entered the commercial market, including the following 5 new products: small molecule ixabepilone, retapamulin, trabectedin, and the peptides exenatide and ziconotide. Clearly, natural product drug discovery programs continue to play a significant role in the clinical development of new therapies in the biopharmaceutical industry.
The river season has now started so if you fancy trying your luck on the Chelmer & Blackwater canal you can now do so, either as a member at no extra charge or as a non member paying for a day ticket. These cost £6 for adults, £ concessions and only £2 for juniors (under 16 years old) on the bank or £5 for adults, £3 concessions and £2 for juniors if purchased in advance of fishing from JP Tackle. Members of Maldon AS can also night fish the canal at no extra charge and also have exclusive fishing on our stretch of the River Blackwater at Wickham Bishops / Langford.
Transdermal patches (adhesive patches placed on the skin) may also be used to deliver a steady dose through the skin and into the bloodstream. Testosterone-containing creams and gels that are applied daily to the skin are also available, but absorption is inefficient (roughly 10%, varying between individuals) and these treatments tend to be more expensive. Individuals who are especially physically active and/or bathe often may not be good candidates, since the medication can be washed off and may take up to six hours to be fully absorbed. There is also the risk that an intimate partner or child may come in contact with the application site and inadvertently dose himself or herself; children and women are highly sensitive to testosterone and can suffer unintended masculinization and health effects, even from small doses. Injection is the most common method used by individuals administering AAS for non-medical purposes.